Chosen Solution

Title says it all. Late 2013 MBPr froze up while using it yesterday. I diagnosed it as best as I could. It boots just fine from a USB drive. The screen, keyboard, and trackpad all work. But the MBPr doesn’t “see” its internal SSD, Thunderbolt 2 external devices (eg, external HDD, TB2 to Ethernet dongle). And the WiFi is completely MIA. I verified that the MBPr thinks all this hardware is “missing” via System Profiler while booted via USB. I tried an SMC reset but that didn’t help. Any thoughts? Is it possible this can be fixed by replacing the I/O cable? Or is the problem much worse, and should I just bite the bullet and make a Genius Bar appointment? Thanks!

If you can’t access your SSD you likely have a deeper problem. Time to visit an Apple Store.