Chosen Solution
I also have the error 53 My screen was never replaced- I DID replaced the flex cable- Phone was dropped in water but no signs of corrosion- even the liquid sensors did not change color- After the phone was dropped- i let the phone “dry out” I did not remover the battery BUT the phone worked fine for over a month with no lasting effects of the water- The issue started when I “erased all content” through the phone- it locked up so I figured I would just update it- This is where error 53 happened- it was bout 5-% done when the error popped up— Nothing in the phone was corroded – I changed the flex cable because I read that was a common issue- but I didn’t fix mine…
Sounds very similar to my error 53 issue. I swapped out a new LCD Shield plate which had the home button cable and was able to then restore. I assume that’s what you also replaced when you are talking about the flex cable? If you have perhaps its related to the home button / Touch ID assembly which can’t be replaced to restore the device.